Biomathematics of Rate Sensitivity: Tachyphylaxis and Tolerance


Tachy 1Fig.  1

Tachyphylaxis is indicated by the transient responses to four constant excitations at various levels but for the same duration. The spiky responses all return to the same basal (steady state) level. By the end of the excitation negative responses occur, i.e.,below the basal level after the sudden discontinuation of the constant excitation.


Fig. 2

Often repeated short excitation result in diminished responses, as in the drug tolerance development, here shown by the two consecutive short excitation of the same intensity. This lack of system responsiveness to short repeated excitations can be compensated by increasing the intensity of further short excitation, which in the practical application may result in an addictive condition. Furthermore, if enough time is allowed to elapse between the two consecutive same excitations (compare the first and the second excitation at the end of the graph), the response nearly returns to the height of response…

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